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Email required Address never made public. Name required. Facebook Twitter YouTube Search for:. Create a free website or blog at WordPress. Follow Following. Sign me up. Already have a WordPress. Log in now. Although withdrawn from the European market in March , there are still flupirtine tablets in many households, and most people are unaware of the hazards they might be facing. A year-old man was admitted to the ED after a suicide attempt with 1 g of flupirtine.

He was lethargic and confused but presented no focal neurological deficits or other symptoms, and the rest of his clinical examination was unremarkable. His cerebral CAT and blood chemistry showed no alterations. The only remarkable feature was that he had green urine. After a careful literature search, a similar case was found caused by flupirtine intoxication.

After 24 hours of vigilance in the ED, he improved his neurological status and his urine lost part of its greenish color. He was then transferred to the Psychiatric Department, where he presented a complete remission of the clinical alterations. A follow-up check-up showed no permanent deficits.

It was commercially used for the first time in Europe in for moderate-to-severe cases of acute pain [ 2 ]. Because of its muscle relaxant properties, it was frequently used for the treatment of orthopedic pain, migraines, and even neoplastic pain.

However, due to an increase in the number of cases reporting liver toxicity after the use of flupirtine, in , its use was restricted, becoming prohibited in Europe in [ 3 , 4 ]. Because this prohibition in Europe is relatively new, there are still a considerable number of households that have flupirtine tablets. For this reason, we present this case to highlight an extremely rare side effect of flupirtine, which has only been reported once to our knowledge.

A year-old man with a known medical history of arterial hypertension and type 2 diabetes mellitus was admitted to the Emergency Department ED for prostration in the last 14 hours. According to his wife, he had taken 10 mg tablets of flupirtine in a suicide attempt. She also reported that in the last three months he had stopped all his usual medications clopidogrel, metformin, telmisartan, simvastatin , but denied changes in his behavior or other alterations. On admission to the ED, the patient was lethargic, with a sparse verbal response.

The clinical team discussed the case with the National Anti-Poisoning Center and received information that this alteration, namely, the change in the normal color of urine, was plausible in cases of flupirtine intoxication although with no certainty. The patient was then observed by the Neurology Department. After a careful literature search, a similar case of greenish urine following flupirtine intoxication was found in the literature [ 5 ]. He was monitored for the next 24 hours in the ED.

Gradually, he became more reactive, and his urine lost some of its greenish color. At the time of discharge from the ED to a psychiatric unit, he was aware, although depressed, and showed no other clinical alterations. Flupirtine is a potent non-opioid analgesic, which is useful in many cases of moderate-to-severe acute pain.

Use the bathroom right before those Marvel opening titles roll. She said that if you normally sleep seven or eight hours a night without needing to get up to urinate, and you can hold it for a few hours during the day, then you should be fine. Bring a sweater.

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